Many people living in the Southern U.S. face a multitude of serious societal and systemic challenges that contribute to the HIV epidemic in the region. The burden of poverty, stigma, and prejudice, low health literacy, and lack of insurance and access to care are among the critical challenges that people living with or affected by HIV face in the region.3 Addressing the HIV/AIDS crisis is not limited to issues of healthcare access and delivery, but also involves navigating cultural norms and social determinants of health that contribute to the epidemic.